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Blood, 10 September 2009, Vol. 114, No. 11, pp. 2263-2272. Prepublished online as a Blood First Edition Paper on June 8, 2009; DOI 10.1182/blood-2009-01-200410. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2009-01-200410v1 114/11/2263    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Google Scholar Articles by van Halteren, A. G. S. Articles by Goulmy, E. PubMed PubMed Citation Articles by van Halteren, A. G. S. Articles by Goulmy, E. Related Collections Immunobiology Free Research Articles Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Naturally acquired tolerance and sensitization to minor histocompatibility antigens in healthy family members Astrid G. S. van Halteren1, Ewa Jankowska-Gan2, Antoinette Joosten1, Els Blokland1, Jos Pool1, Anneke Brand1,3, William J. Burlingham2, and Els Goulmy1 1 Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands; 2 Department of Surgery, University of Wisconsin, Madison; and 3 Sanquin Blood Bank South West, Leiden, The Netherlands Bidirectional cell transfer during pregnancy frequently leads to postpartum persistence of allogeneic cells and alloimmune responses in both the mother and in her offspring. The life-long consequences of naturally acquired alloimmune reactivity are probably of importance for the outcome of allogeneic stem cell transplantation. We investigated the presence of CD8pos minor histocompatibility (H) antigen–specific cytotoxic T lymphocytes (TCTL) and CD8pos minor H antigen–specific T regulator cells (TREG) in peripheral blood cells obtained from 17 minor H antigen–disparate mother-offspring pairs. Absence of minor H antigen–specific TREG, as marked by the feasibility to expand TCTL from isolated tetramerpos populations, was observed in 6 mothers and 1 son. The presence of minor H alloantigen–specific TREG was observed in 4 mothers and 5 sons. These TREG were detected within isolated tetramerdim staining fractions and functioned in a CTLA-4–dependent fashion. Our study indicates that both TCTL and TREG mediated alloimmunity against minor H antigens may be present in healthy female and male hematopoietic stem cell donors, potentially influencing graft-versus-host reactivity in different ways. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Tolerance: pregnancy matters Franco Locatelli Blood 2009 114: 2208-2209. [Full Text] [PDF] This article has been cited by other articles: P. Dutta, M. Molitor-Dart, J. L. Bobadilla, D. A. Roenneburg, Z. Yan, J. R. Torrealba, and W. J. Burlingham Microchimerism is strongly correlated with tolerance to noninherited maternal antigens in mice Blood, October 22, 2009; 114(17): 3578 - 3587. [Abstract] [Full Text] [PDF] F. Locatelli Tolerance: pregnancy matters Blood, September 10, 2009; 114(11): 2208 - 2209. [Full Text] [PDF]

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