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Blood, 17 September 2009, Vol. 114, No. 12, pp. 2367-2374. Prepublished online as a Blood First Edition Paper on July 7, 2009; DOI 10.1182/blood-2009-05-199208. This Article Full Text Full Text (PDF) Supplemental Table All Versions of this Article: blood-2009-05-199208v1 114/12/2367    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Google Scholar Articles by Delvaeye, M. Articles by Conway, E. M. PubMed PubMed Citation Articles by Delvaeye, M. Articles by Conway, E. M. Related Collections Perspectives Thrombosis and Hemostasis Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  PERSPECTIVE Coagulation and innate immune responses: can we view them separately? Mieke Delvaeye1,*, and Edward M. Conway1,2,* 1 Vesalius Research Center (VRC), University of Leuven (KUL), Leuven, Belgium; and 2 Centre for Blood Research, Faculty of Medicine, University of British Columbia, Vancouver, BC The horseshoe crab is often referred to as a "living fossil," representative of the oldest classes of arthropods, almost identical to species in existence more than 500 million years ago. Comparative analyses of the defense mechanisms used by the horseshoe crab that allowed it to survive mostly unchanged throughout the millennia reveal a common ancestry of the coagulation and innate immune systems that are totally integrated—indeed, almost inseparable. In human biology, we traditionally view the hemostatic pathways and those regulating innate immune responses to infections and tissue damage as entirely separate entities. But are they? The last couple of decades have revealed a remarkable degree of interplay between these systems, and the linking cellular and molecular mechanisms are rapidly being delineated. In this review, we present some of the major points of intersection between coagulation and innate immunity. We attempt to highlight the potential impact of these findings by identifying recently established paradigms that will hopefully result in the emergence of new strategies to treat a range of inflammatory and hemostatic disorders. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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