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 Blood, 24 September 2009, Vol. 114, No. 13, pp. 2623-2631.
Prepublished online as a Blood First Edition Paper on August 3, 2009; DOI 10.1182/blood-2008-10-183301.

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IMMUNOBIOLOGY

Dynamic accumulation of plasmacytoid dendritic cells in lymph nodes is regulated by interferon-β

Yunfei Gao1, Beata Majchrzak-Kita1,2, Eleanor N. Fish1,2, and Jennifer L. Gommerman1

1 Department of Immunology, University of Toronto, Toronto; and 2 Toronto General Research Institute, University Health Network, Toronto, ON

Plasmacytoid dendritic cells (pDCs) represent a major cellular component of our front-line defense against viruses because of their capacity to rapidly secrete type I interferon (IFN)–{alpha} and -β after infection. Constant immunosurveillance of the host requires that lymphocytes traffic through lymph nodes (LNs) to sample antigen, yet little is known about the dynamics of pDC accumulation within the secondary lymphoid organs. Here we show that pDCs readily accumulate within the secondary lymphoid organs of mice after virus infection. Interestingly, retention of pDC within LNs is enhanced in the presence of the sphingoshine-1-phosphate receptor agonist FTY720 in a manner similar to that observed for B and T lymphocytes. Ex vivo comparison of mouse pDCs with lymphocytes revealed that pDCs express sphingoshine-1-phosphate 4 and also constitutively express CD69, which is further up-regulated upon virus infection. In IFN-β–/– mice, accumulation of pDC and lymphocytes within LNs is reduced both during viral infection and under steady state conditions, and these defects can be reversed by adding recombinant IFN-β in vivo. These data suggest that pDC and lymphocytes use similar mechanisms for retention within LNs and that these processes are influenced by IFN-β even in the absence of viral infection.


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