SEARCH:   Advanced

Blood, 1 October 2009, Vol. 114, No. 14, pp. 2878-2883. Prepublished online as a Blood First Edition Paper on July 17, 2009; DOI 10.1182/blood-2009-05-219915. This Article Full Text Full Text (PDF) Supplemental Table All Versions of this Article: blood-2009-05-219915v1 114/14/2878    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Google Scholar Articles by Cushman, M. Articles by Heckbert, S. R. PubMed PubMed Citation Articles by Cushman, M. Articles by Heckbert, S. R. Related Collections Free Research Articles Thrombosis and Hemostasis Clinical Trials and Observations Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS Coagulation factors IX through XIII and the risk of future venous thrombosis: the Longitudinal Investigation of Thromboembolism Etiology Mary Cushman1, Ellen S. O'Meara2, Aaron R. Folsom3, and Susan R. Heckbert4 1 Departments of Medicine and Pathology, University of Vermont, Burlington; 2 Department of Biostatistics, University of Washington, Seattle; 3 Division of Epidemiology and Community Health, University of Minnesota, Minneapolis; and 4 Department of Epidemiology, University of Washington, Seattle Higher levels of procoagulant factors and factor XII deficiency may be risk factors for first venous thromboembolism (VTE). We studied associations of coagulation factors IX through XIII with risk of future VTE in 2 general population samples. Using a nested case-control study combining the 21 860 participants of the Atherosclerosis Risk in Communities study and the Cardiovascular Health Study, we determined antigenic levels of these coagulation factors in primarily pre-event blood samples from 462 participants who subsequently developed VTE and 1047 participants who remained free of VTE. Only elevated levels of factors IX and XI were associated with increased risk of VTE after adjustment for age, sex, race, and study. For factor IX, the odds ratio (OR) was 1.4 (95% confidence interval [CI], 1.0-2.0) comparing the top to bottom quintile. The OR for factor XI was higher: 2.0 (95% CI, 1.4-2.9). With further adjustment for body mass index and diabetes, only elevated factor XI remained associated with VTE risk: OR 1.8 (95% CI, 1.3-2.7). Associations were similar by study and whether the thrombosis was idiopathic or secondary. Factor XII deficiency was not related to VTE risk. Among these procoagulant factors, only elevated factor XI was a risk factor for VTE. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: High coagulant factors & venous thrombosis Carine J. M. Doggen Blood 2009 114: 2854-2855. [Full Text] [PDF] This article has been cited by other articles: C. J. M. Doggen High coagulant factors & venous thrombosis Blood, October 1, 2009; 114(14): 2854 - 2855. [Full Text] [PDF]

	Copyright © 2009 by American Society of Hematology         Online ISSN: 1528-0020