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Blood, 8 October 2009, Vol. 114, No. 15, pp. 3133-3134.

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InsideBlood

CLINICAL TRIALS

Comment on Gentles et al, page 3158

Stem cell mimicry: key to transformation?

Emanuela Carlotti, and John G. Gribben

BARTS AND THE LONDON SCHOOL OF MEDICINE AND DENTISTRY

Abstract

In this issue of Blood, Gentles and colleagues used a computational model to investigate FL and transformed DLBCL, and identified the acquisition of an ESC-like signature as a key feature of transformation.1


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Related Article in Blood Online:

A pluripotency signature predicts histologic transformation and influences survival in follicular lymphoma patients
Andrew J. Gentles, Ash A. Alizadeh, Su-In Lee, June H. Myklebust, Catherine M. Shachaf, Babak Shahbaba, Ronald Levy, Daphne Koller, and Sylvia K. Plevritis
Blood 2009 114: 3158-3166. [Abstract] [Full Text] [PDF]





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