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Blood, 8 October 2009, Vol. 114, No. 15, pp. 3136-3137.

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InsideBlood

VASCULAR BIOLOGY

Comment on Suzuki et al, page 3352

Can RAP save your brain?

Anton J. G. Horrevoets

VU UNIVERSITY MEDICAL CENTER

Abstract

In this issue of Blood, Suzuki and colleagues report that the bleeding complications associated with thrombolytic therapy after ischemic stroke might be counteracted by RAP, the receptor-associated protein that inhibits ischemia-induced LRP, a signaling receptor for t-PA.


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Related Article in Blood Online:

Tissue-type plasminogen activator (t-PA) induces stromelysin-1 (MMP-3) in endothelial cells through activation of lipoprotein receptor–related protein
Yasuhiro Suzuki, Nobuo Nagai, Kasumi Yamakawa, Junichi Kawakami, H. Roger Lijnen, and Kazuo Umemura
Blood 2009 114: 3352-3358. [Abstract] [Full Text] [PDF]





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