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 Blood, 22 October 2009, Vol. 114, No. 17, pp. 3652-3655.
Prepublished online as a Blood First Edition Paper on August 25, 2009; DOI 10.1182/blood-2009-07-231894.

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RED CELLS, IRON, AND ERYTHROPOIESIS

Brief report

Stage-specific susceptibility of human erythroblasts to Plasmodium falciparum malaria infection

Pamela A. Tamez1, Hui Liu2, Sebastian Fernandez-Pol1, Kasturi Haldar1, and Amittha Wickrema2

1 Center for Rare and Neglected Diseases, University of Notre Dame, South Bend, IN; and 2 Department of Medicine, University of Chicago, IL

Malaria parasites are known to invade and develop in erythrocytes and reticulocytes, but little is known about their infection of nucleated erythroid precursors. We used an in vitro cell system that progressed through basophilic, polychromatic, orthochromatic, and reticulocyte stages to mature erythrocytes. We show that orthochromatic cells are the earliest stages that may be invaded by Plasmodium falciparum, the causative agent of fatal human malaria. Susceptibility to invasion is distinct from intracellular survival and occurs at a time of extensive erythroid remodeling. Together these data suggest that the potential for complexity of host interactions involved in infection may be vastly greater than hitherto realized.


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