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Blood, 22 October 2009, Vol. 114, No. 17, pp. 3656-3661. Prepublished online as a Blood First Edition Paper on August 25, 2009; DOI 10.1182/blood-2009-03-212910. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2009-03-212910v1 114/17/3656    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Google Scholar Articles by de Laat, B. Articles by Doggen, C. J. M. PubMed PubMed Citation Articles by de Laat, B. Articles by Doggen, C. J. M. Related Collections Free Research Articles Thrombosis and Hemostasis Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  THROMBOSIS AND HEMOSTASIS Association between beta2-glycoprotein I plasma levels and the risk of myocardial infarction in older men Bas de Laat1, Philip G. de Groot2, Ronald H. W. M. Derksen3, Rolf T. Urbanus2, Koen Mertens1,4, Frits R. Rosendaal57, and Carine J. M. Doggen5,8 1 Department of Plasma Proteins, Sanquin Research, Amsterdam; 2 Department of Clinical Chemistry and Haematology, Thrombosis and Haemostasis Laboratory, University Medical Center, Utrecht; 3 Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht; 4 Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht; 5 Department of Clinical Epidemiology, Leiden University Medical Center, Leiden; 6 Thrombosis and Haemostasis Research Center, Department of Haematology, Leiden University Medical Center, Leiden; 7 Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden; and 8 Department of Health Technology & Services Research, University of Twente, Enschede, The Netherlands von Willebrand factor (VWF) serves as adhesive surface for platelets to adhere to the vessel wall. We have recently found that beta2-glycoprotein I is able to inhibit platelet binding to VWF, indicating a role in the pathophysiology of arterial thrombosis. In the present study, we investigated whether differences in beta2-glycoprotein I plasma levels influence the risk of myocardial infarction. We have measured beta2-glycoprotein I and VWF antigen levels in 539 men with a first myocardial infarction and in 611 control subjects. Although we did not find a profound effect of beta2-glycoprotein I plasma levels on myocardial infarction in the overall population, we found a dose-dependent protective effect of increasing beta2-glycoprotein I plasma levels on myocardial infarction in men 60 years and older. In this age group, we found an odds ratio of 0.41 (95% confidence interval, 0.22-0.74) for high beta2-glycoprotein I levels compared with low levels. High plasma levels of beta2-glycoprotein I remained protective for myocardial infarction despite high levels of VWF. To conclude, high circulating levels of beta2-glycoprotein I appeared to be associated with a reduced risk of myocardial infarction in elderly men. In vivo experiments are needed to investigate the exact contribution of beta2-glycoprotein I on the pathophysiology of myocardial infarction. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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