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Blood, 29 October 2009, Vol. 114, No. 18, pp. 3841-3853. Prepublished online as a Blood First Edition Paper on September 18, 2009; DOI 10.1182/blood-2009-02-202481. This Article Full Text Full Text (PDF) Supplemental Figure All Versions of this Article: blood-2009-02-202481v1 blood-2009-02-202481v2 114/18/3841    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Google Scholar Articles by Zloza, A. Articles by Al-Harthi, L. PubMed PubMed Citation Articles by Zloza, A. Articles by Al-Harthi, L. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Potent HIV-specific responses are enriched in a unique subset of CD8+ T cells that coexpresses CD4 on its surface Andrew Zloza1, Jason M. Schenkel1, Allan R. Tenorio2, Jeffrey A. Martinson1, Paul M. Jeziorczak1, and Lena Al-Harthi1 Departments of 1 Immunology/Microbiology and 2 Internal Medicine, Rush University Medical Center, Chicago, IL In humans, approximately 3% of peripheral CD8+ T cells coexpress CD4 dimly on their surface and hence are designated as CD4dimCD8bright T cells. We evaluated the contribution of this CD4dimCD8bright T-cell population to anti-HIV immunity. We demonstrate that CD4dimCD8bright T cells generate greater than 55% of CD8+ T-cell antigen recognition and effector response to HIV, as evaluated by multiple parameters for assessing T-cell antiviral immunity, including HIV tetramer recognition, cytokine production, and cytolytic potential. Inhibition of major histocompatibility class II (MHC-II) on target cells or CD4 on CD4dimCD8bright T cells diminishes their anti-HIV responses, suggesting that CD4 on effector cells and MHC-II on target cells provides an additional arm of contact between effector and target cells which is critical to CD4dimCD8bright T-cell function. CD4dimCD8bright T cells also exhibit features that are indicative of central memory T cells. Finally, CD4dimCD8bright T cells are elevated in blood of HIV+ long-term nonprogressors in comparison to HIV– donors. Collectively, our findings show that CD4dimCD8bright T cells designate an enriched antiviral subpopulation of CD8+ T cells that should be targeted for therapeutic intervention or evaluation of vaccine efficacy. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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