SEARCH:   Advanced

Blood, 5 November 2009, Vol. 114, No. 19, pp. 4272-4278. Prepublished online as a Blood First Edition Paper on August 18, 2009; DOI 10.1182/blood-2009-05-222380. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2009-05-222380v1 114/19/4272    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Google Scholar Articles by Undas, A. Articles by Tracz, W. PubMed PubMed Citation Articles by Undas, A. Articles by Tracz, W. Related Collections Thrombosis and Hemostasis Clinical Trials and Observations Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  THROMBOSIS AND HEMOSTASIS Altered fibrin clot structure/function in patients with idiopathic venous thromboembolism and in their relatives Anetta Undas1, Krystyna Zawilska2, Mariola Ciesla-Dul3, Agata Lehmann-Kopydowska2, Agnieszka Skubiszak2, Katarzyna Ciepuch2, and Wiesawa Tracz1 1 Institute of Cardiology, Jagiellonian University School of Medicine, Krakow; 2 Department of Hematology, Karol Marcinkowski University of Medical Sciences, Poznan; and 3 John Paul II Hospital, Krakow, Poland We tested the hypothesis that fibrin structure/function is unfavorably altered in patients after idiopathic venous thromboembolism (VTE) and their relatives. Ex vivo plasma fibrin clot permeability, turbidimetry, and efficiency of fibrinolysis were investigated in 100 patients with first-ever VTE, including 34 with pulmonary embolism (PE), 100 first-degree relatives, and 100 asymptomatic controls with no history of thrombotic events. Known thrombophilia, cancer, trauma, and surgery were exclusion criteria. VTE patients and their relatives were characterized by lower clot permeability (P < .001), lower compaction (P < .001), higher maximum clot absorbancy (P < .001), and prolonged clot lysis time (P < .001) than controls, with more pronounced abnormalities, except maximum clot absorbance, in the patients versus relatives (all P < .01). Fibrin clots obtained for PE patients were more permeable, less compact, and were lysed more efficiently compared with deep-vein thrombosis patients (all P < .05) with no differences in their relatives. Being VTE relative, fibrinogen, and C-reactive protein were independent predictors of clot permeability and fibrinolysis time in combined analysis of controls and relatives. We conclude that altered fibrin clot features are associated with idiopathic VTE with a different profile of fibrin variables in PE. Similar features can be detected in VTE relatives. Fibrin properties might represent novel risk factors for thrombosis. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Denser matters Robert A. S. Ariëns Blood 2009 114: 3978-3979. [Full Text] [PDF] This article has been cited by other articles: R. A. S. Ariens Denser matters Blood, November 5, 2009; 114(19): 3978 - 3979. [Full Text] [PDF]

	Copyright © 2009 by American Society of Hematology         Online ISSN: 1528-0020