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Blood, 23 July 2009, Vol. 114, No. 4, pp. 785-790. Prepublished online as a Blood First Edition Paper on January 29, 2009; DOI 10.1182/blood-2008-12-192575. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2008-12-192575v1 114/4/785    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Google Scholar Articles by Vachon, C. M. Articles by Rajkumar, S. V. PubMed PubMed Citation Articles by Vachon, C. M. Articles by Rajkumar, S. V. Related Collections Free Research Articles Lymphoid Neoplasia Clinical Trials and Observations Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS Increased risk of monoclonal gammopathy in first-degree relatives of patients with multiple myeloma or monoclonal gammopathy of undetermined significance Celine M. Vachon1, Robert A. Kyle2, Terry M. Therneau3, Barbara J. Foreman1, Dirk R. Larson3, Colin L. Colby3, Tara K. Phelps2, Angela Dispenzieri2, Shaji K. Kumar2, Jerry A. Katzmann4, and S. Vincent Rajkumar2 1 Division of Epidemiology, Department of Health Sciences Research, 2 Division of Hematology, Department of Internal Medicine, 3 Division of Biostatistics, Department of Health Science Research, and 4 Department of Laboratory Medicine and Pathology, College of Medicine, Mayo Clinic, Rochester, MN We examined whether monoclonal gammopathy of undetermined significance (MGUS) is increased in first-degree relatives of multiple myeloma (MM) or MGUS patients. Probands were recruited from a population-based prevalence study (MGUS) and the Mayo Clinic (MM). Serum samples were collected from first-degree relatives older than 40 years and subjected to electrophoresis and immunofixation. The prevalence of MGUS in relatives was compared with population-based rates. Nine-hundred eleven relatives of 232 MM and 97 MGUS probands were studied. By electrophoresis, MGUS was detected in 55 (6%) relatives, and immunofixation identified 28 additional relatives for an age- and sex-adjusted prevalence of 8.1% (95% CI, 6.3 to 9.8). The prevalence of MGUS in relatives increased with age (1.9%, 6.9%, 11.6%, 14.6%, 21.0% for ages 40-49, 50-59, 60-69, 70-79, 80 years, respectively; P < .001). Using similar MGUS detection methods, there was a higher risk of MGUS in relatives (age-adjusted risk ratio [RR], 2.6; 95% CI, 1.9 to 3.4) compared with the reference population. The increased risk was seen among relatives of MM (RR, 2.0; 95% CI, 1.4 to 2.8) and MGUS probands (RR, 3.3; 95% CI, 2.1 to 4.8). The increased risk of MGUS in first-degree relatives of MGUS or MM patients implies shared environment and/or genetics. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Familial multiple myeloma Henry T. Lynch and Stephan D. Thomé Blood 2009 114: 749-750. [Full Text] [PDF] This article has been cited by other articles: S. Y. Kristinsson, L. R. Goldin, M. Bjorkholm, J. Koshiol, I. Turesson, and O. Landgren Genetic and immune-related factors in the pathogenesis of lymphoproliferative and plasma cell malignancies Haematologica, November 1, 2009; 94(11): 1581 - 1589. [Abstract] [Full Text] [PDF] H. T. Lynch and S. D. Thome Familial multiple myeloma Blood, July 23, 2009; 114(4): 749 - 750. [Full Text] [PDF]

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