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Blood, 23 July 2009, Vol. 114, No. 4, pp. 791-795. Prepublished online as a Blood First Edition Paper on January 30, 2009; DOI 10.1182/blood-2008-12-191676. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2008-12-191676v1 114/4/791    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Google Scholar Articles by Landgren, O. Articles by Turesson, I. PubMed PubMed Citation Articles by Landgren, O. Articles by Turesson, I. Related Collections Free Research Articles Lymphoid Neoplasia Clinical Trials and Observations Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS Risk of plasma cell and lymphoproliferative disorders among 14621 first-degree relatives of 4458 patients with monoclonal gammopathy of undetermined significance in Sweden Ola Landgren13, Sigurdur Y. Kristinsson3, Lynn R. Goldin1, Neil E. Caporaso1, Cecilie Blimark4, Ulf-Henrik Mellqvist4, Anders Wahlin5, Magnus Bjorkholm3, and Ingemar Turesson6 1 Division of Cancer Epidemiology and Genetics, and 2 Center for Cancer Research, Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD; 3 Department of Medicine, Division of Hematology, Karolinska University Hospital and Institutet, Stockholm, Sweden; 4 Department of Medicine, Section of Hematology and Coagulation, Sahlgrenska University Hospital, Gothenburg, Sweden; 5 Section of Hematology, Umeå University Hospital, Umea, Sweden; and 6 Department of Medicine, Section of Hematology, Malmö University Hospital, Malmö, Sweden Familial clustering of the precursor condition, monoclonal gammopathy of undetermined significance (MGUS) has been observed in case reports and in smaller studies. Using population-based data from Sweden, we identified 4458 MGUS patients, 17505 population-based controls, and first-degree relatives of patients (n = 14621) and controls (n = 58387) with the aim to assess risk of MGUS and lymphoproliferative malignancies among first-degree relatives of MGUS patients. Compared with relatives of controls, relatives of MGUS patients had increased risk of MGUS (relative risk [RR] = 2.8; 1.4-5.6), multiple myeloma (MM; RR = 2.9; 1.9-4.3), lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM; RR = 4.0; 1.5-11), and chronic lymphocytic leukemia (CLL; RR = 2.0; 1.2-2.3). Relatives of patients with IgG/IgA MGUS had a 4.0-fold (1.7-9.2), 2.9-fold (1.7-4.9), and 20-fold (2.3-170) elevated risk of developing MGUS, MM, and LPL/WM, respectively. Relatives of IgM MGUS patients had 5.0-fold (1.1-23) increased CLL risk and nonsignificant excess MM and LPL/WM risks. The results were very similar when we assessed risk by type of first-degree relative, age at MGUS (above/below 65 years), or sex. Risk of non-Hodgkin lymphoma or Hodgkin lymphoma was not increased among MGUS relatives. Among first-degree relatives of a nationwide MGUS cohort, we found elevated risks of MGUS, MM, LPL/WM, and CLL, supporting a role for germline susceptibility genes, shared environmental influences, or an interaction between both. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Familial multiple myeloma Henry T. Lynch and Stephan D. Thomé Blood 2009 114: 749-750. [Full Text] [PDF] This article has been cited by other articles: S. Y. Kristinsson, L. R. Goldin, M. Bjorkholm, J. Koshiol, I. Turesson, and O. Landgren Genetic and immune-related factors in the pathogenesis of lymphoproliferative and plasma cell malignancies Haematologica, November 1, 2009; 94(11): 1581 - 1589. [Abstract] [Full Text] [PDF] H. T. Lynch and S. D. Thome Familial multiple myeloma Blood, July 23, 2009; 114(4): 749 - 750. [Full Text] [PDF] O. Landgren, R. A. Kyle, J. A. Hoppin, L. E. Beane Freeman, J. R. Cerhan, J. A. Katzmann, S. V. Rajkumar, and M. C. Alavanja Pesticide exposure and risk of monoclonal gammopathy of undetermined significance in the Agricultural Health Study Blood, June 18, 2009; 113(25): 6386 - 6391. [Abstract] [Full Text] [PDF]

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