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Blood, 30 July 2009, Vol. 114, No. 5, pp. 929-930. This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Google Scholar Articles by Kremer, E. J. PubMed PubMed Citation Articles by Kremer, E. J. Related Collections Related Article in Blood Online Social Bookmarking                   What's this? Next Article  GENE THERAPY Comment on Alba et al, page 965 Mutagenesis of hexon "FX" hepatic tropism Eric J. Kremer INSTITUT DE GÉNÉTIQUE MOLÉCULAIRE DE MONTPELLIER Abstract In this issue of Blood, Alba and colleagues identify key amino acids in adenovirus hexon hypervariable regions that interact with coagulation factor X. By mutating these residues on the adenovirus's major capsid protein in Ad-based vectors, the authors succeed in retargeting gene transfer away from hepatocytes. The advances achieved in this study may create a vector platform that can be used to develop Ad-based therapeutics for nonliver-targeted diseases. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer Raul Alba, Angela C. Bradshaw, Alan L. Parker, David Bhella, Simon N. Waddington, Stuart A. Nicklin, Nico van Rooijen, Jerome Custers, Jaap Goudsmit, Dan H. Barouch, John H. McVey, and Andrew H. Baker Blood 2009 114: 965-971. [Abstract] [Full Text] [PDF]

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