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Blood, 30 July 2009, Vol. 114, No. 5, pp. 931-932.

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InsideBlood

LYMPHOID NEOPLASIA

Comment on Hideshima et al, page 1046

Bortezomib paradigm shift in myeloma

David J. McConkey

MD ANDERSON CANCER CENTER

Abstract

Bortezomib's unprecedented antitumor activity in myeloma has long been attributed to NF-{kappa}B inhibition. A new study from the group that put the drug on the map directly challenges this assumption.


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Related Article in Blood Online:

Bortezomib induces canonical nuclear factor-{kappa}B activation in multiple myeloma cells
Teru Hideshima, Hiroshi Ikeda, Dharminder Chauhan, Yutaka Okawa, Noopur Raje, Klaus Podar, Constantine Mitsiades, Nikhil C. Munshi, Paul G. Richardson, Ruben D. Carrasco, and Kenneth C. Anderson
Blood 2009 114: 1046-1052. [Abstract] [Full Text] [PDF]





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