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Blood, 30 July 2009, Vol. 114, No. 5, pp. 937-951. Prepublished online as a Blood First Edition Paper on April 8, 2009; DOI 10.1182/blood-2009-03-209262. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2009-03-209262v1 114/5/937    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Google Scholar Articles by Vardiman, J. W. Articles by Bloomfield, C. D. PubMed PubMed Citation Articles by Vardiman, J. W. Articles by Bloomfield, C. D. Related Collections Perspectives Free Research Articles Myeloid Neoplasia Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  PERSPECTIVE The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes James W. Vardiman1, Jüergen Thiele2, Daniel A. Arber3, Richard D. Brunning4, Michael J. Borowitz5, Anna Porwit6, Nancy Lee Harris7, Michelle M. Le Beau8, Eva Hellström-Lindberg9, Ayalew Tefferi10, and Clara D. Bloomfield11 1 Department of Pathology, University of Chicago, IL; 2 Institute of Pathology, University of Cologne, Cologne, Germany; 3 Department of Pathology, Stanford University Medical Center, CA; 4 Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis; 5 Department of Pathology and Oncology, Johns Hopkins Medical Institutions, Baltimore, MD; 6 Department of Pathology, Karolinska University Hospital, Stockholm, Sweden; 7 Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston; 8 Section of Hematology/Oncology, University of Chicago, IL; 9 Department of Medicine, Karolinska University Hospital, Stockholm, Sweden; 10 Division of Hematology, Mayo Clinic, Rochester, MN; and 11 Comprehensive Cancer Center, The Ohio State University, Columbus Recently the World Health Organization (WHO), in collaboration with the European Association for Haematopathology and the Society for Hematopathology, published a revised and updated edition of the WHO Classification of Tumors of the Hematopoietic and Lymphoid Tissues. The 4th edition of the WHO classification incorporates new information that has emerged from scientific and clinical studies in the interval since the publication of the 3rd edition in 2001, and includes new criteria for the recognition of some previously described neoplasms as well as clarification and refinement of the defining criteria for others. It also adds entities—some defined principally by genetic features—that have only recently been characterized. In this paper, the classification of myeloid neoplasms and acute leukemia is highlighted with the aim of familiarizing hematologists, clinical scientists, and hematopathologists not only with the major changes in the classification but also with the rationale for those changes. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Tefferi and J. W. Vardiman Myelodysplastic Syndromes N. Engl. J. Med., November 5, 2009; 361(19): 1872 - 1885. [Full Text] [PDF] A. D. Klion How I treat hypereosinophilic syndromes Blood, October 29, 2009; 114(18): 3736 - 3741. [Abstract] [Full Text] [PDF] K. I. Mills, A. Kohlmann, P. M. Williams, L. Wieczorek, W.-m. Liu, R. Li, W. Wei, D. T. Bowen, H. Loeffler, J. M. Hernandez, et al. Microarray-based classifiers and prognosis models identify subgroups with distinct clinical outcomes and high risk of AML transformation of myelodysplastic syndrome Blood, July 30, 2009; 114(5): 1063 - 1072. [Abstract] [Full Text] [PDF]

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