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Blood, 6 August 2009, Vol. 114, No. 6, pp. 1276-1279. Prepublished online as a Blood First Edition Paper on May 12, 2009; DOI 10.1182/blood-2009-03-209981. This Article Full Text Full Text (PDF) Supplemental Methods and Tables All Versions of this Article: blood-2009-03-209981v1 114/6/1276    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Google Scholar Articles by Brooks, E. G. Articles by Bovill, E. G. PubMed PubMed Citation Articles by Brooks, E. G. Articles by Bovill, E. G. Related Collections Thrombosis and Hemostasis Vascular Biology Brief Reports Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  VASCULAR BIOLOGY Brief report Valves of the deep venous system: an overlooked risk factor Erin G. Brooks1,*, Winifred Trotman1,*, Marilyn P. Wadsworth1, Douglas J. Taatjes1, Mark F. Evans1, Frank P. Ittleman2, Peter W. Callas3, Charles T. Esmon4, and Edwin G. Bovill1 Departments of 1 Pathology, 2 Surgery/Thoracic-Cardiovascular, and 3 Mathematics/Statistics, University of Vermont, Burlington; and 4 The Howard Hughes Medical Institute, Oklahoma Medical Research Foundation, Oklahoma City Deep venous valves are frequent sites of deep venous thrombosis initiation. However, the possible contribution of the valvular sinus endothelium has received little attention in studies of thrombosis risk. We hypothesized that the endothelium of valve sinus differs from that of vein lumen with up-regulation of anticoagulant and down-regulation of procoagulant activities in response to the local environment. In pursuit of this hypothesis, we quantified endothelial protein C receptor (EPCR), thrombomodulin (TM), and von Willebrand factor (VWF) by immunofluorescence in great saphenous veins harvested at cardiac bypass surgery. We found significantly increased expression of EPCR and TM in the valvular sinus endothelium as opposed to the vein lumenal endothelium, and the opposite pattern with VWF (paired t test for TM and EPCR, each P < .001; for VWF, P = .01). These data support our hypothesis and suggest that variation in valvular sinus thromboresistance may be an important factor in venous thrombogenesis. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Is Virchow's triad complete? Paul A. Kyrle and Sabine Eichinger Blood 2009 114: 1138-1139. [Full Text] [PDF] This article has been cited by other articles: S. J. Hasstedt, I. D. Bezemer, P. W. Callas, C. Y. Vossen, W. Trotman, R. P. Hebbel, C. Demers, F. R. Rosendaal, and E. G. Bovill Cell adhesion molecule 1: a novel risk factor for venous thrombosis Blood, October 1, 2009; 114(14): 3084 - 3091. [Abstract] [Full Text] [PDF] P. A. Kyrle and S. Eichinger Is Virchow's triad complete? Blood, August 6, 2009; 114(6): 1138 - 1139. [Full Text] [PDF]

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