SEARCH:   Advanced

Blood, 13 August 2009, Vol. 114, No. 7, pp. 1306-1313. Prepublished online as a Blood First Edition Paper on May 18, 2009; DOI 10.1182/blood-2009-02-202762. This Article Full Text Full Text (PDF) Supplemental Appendix All Versions of this Article: blood-2009-02-202762v1 114/7/1306    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Google Scholar Articles by Re, A. Articles by Rossi, G. PubMed PubMed Citation Articles by Re, A. Articles by Rossi, G. Related Collections Transplantation Free Research Articles Lymphoid Neoplasia Clinical Trials and Observations Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS High-dose therapy and autologous peripheral blood stem cell transplantation as salvage treatment for AIDS-related lymphoma: long-term results of the Italian Cooperative Group on AIDS and Tumors (GICAT) study with analysis of prognostic factors Alessandro Re1, Mariagrazia Michieli2, Salvatore Casari3, Bernardino Allione4, Chiara Cattaneo1, Maurizio Rupolo2, Michele Spina5, Rosa Manuele2, Emanuela Vaccher5, Mario Mazzucato6, Luciano Abbruzzese6, Pierino Ferremi7, Giampiero Carosi3, Umberto Tirelli5, and Giuseppe Rossi1 1 Division of Hematology, Spedali Civili di Brescia, Brescia; 2 Cell Therapy and High Dose Chemotherapy Unit, National Cancer Institute, Aviano; 3 Clinic of Infectious Disease, University of Brescia, Brescia; 4 Division of Hematology, Ospedale SS Antonio e Biagio, Alessandria; 5 Division of Medical Oncology A, National Cancer Institute, Aviano; 6 Department of Laboratory Medicine and Cell Therapy, Hematopoietic Stem Cells Collection and Processing Unit, National Cancer Institute, Aviano; and 7 Department of Immune-Hematology and Transfusional Medicine, Spedali Civili di Brescia, Brescia, Italy After the introduction of highly active antiretroviral therapy (HAART), intensive treatment, including high-dose therapy (HDT) and peripheral blood stem cell transplantation (PBSCT), has become feasible in HIV-positive patients with Hodgkin (HL) and non-Hodgkin (NHL) lymphoma. Herein, we report the long-term results, on an intention-to-treat basis, of a prospective study on HDT and PBSCT in 50 HIV-positive HAART-responding patients with refractory/relapsed lymphoma. After debulking therapy, 2 patients had early toxic deaths, 10 had chemoresistant disease, 6 failed stem cell mobilization, 1 refused collection, and 4 progressed soon after PBSC harvest. Twenty-seven actually received transplant. Twenty-one patients are alive and disease-free after a median follow-up of 44 months (OS, 74.6%; PFS, 75.9%). Only lymphoma response significantly affected OS after transplantation. In multivariate analyses both lymphoma stage and low CD4 count negatively influenced the possibility to receive transplant. Median OS of all 50 eligible patients was 33 months (OS, 49.8%; PFS, 48.9%). Low CD4 count, marrow involvement, and poor performance status independently affected survival. PBSCT is a highly effective salvage treatment for chemosensitive AIDS-related lymphoma. It seems rational to explore its use earlier during the course of lymphoma to increase the proportion of patients who can actually receive transplant. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Stem cell transplantation in AIDS-lymphoma Alexandra M. Levine Blood 2009 114: 1284-1285. [Full Text] [PDF] This article has been cited by other articles: A. M. Levine Stem cell transplantation in AIDS-lymphoma Blood, August 13, 2009; 114(7): 1284 - 1285. [Full Text] [PDF]

	Copyright © 2009 by American Society of Hematology         Online ISSN: 1528-0020