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 Blood, 20 August 2009, Vol. 114, No. 8, pp. 1456-1457.

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InsideBlood

CLINICAL TRIALS

Comment on Reece et al, page 1489

Finishing off fibrils

Morie Gertz

MAYO CLINIC

Abstract

Bortezomib shows high activity in light chain amyloidosis. Responses occur rapidly and are seen in cardiac, renal, and hepatic disease. Toxicity in this fragile population is significant.


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Related Article in Blood Online:

Weekly and twice-weekly bortezomib in patients with systemic AL amyloidosis: results of a phase 1 dose-escalation study
Donna E. Reece, Vaishali Sanchorawala, Ute Hegenbart, Giampaolo Merlini, Giovanni Palladini, Jean-Paul Fermand, Robert A. Vescio, Xiangyang Liu, Yusri A. Elsayed, Andrew Cakana, Raymond L. Comenzo, and for the VELCADE CAN2007 Study Group
Blood 2009 114: 1489-1497. [Abstract] [Full Text] [PDF]





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