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 Blood, 20 August 2009, Vol. 114, No. 8, pp. 1457-1458.

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InsideBlood

IMMUNOBIOLOGY

Comment on Mumprecht et al, page 1528,Zhang et al, page 1545, andAhmadzadeh et al, page 1537

Blocking PD-1 in cancer immunotherapy

Gianpietro Dotti

BAYLOR COLLEGE OF MEDICINE

Abstract

The PD-1 pathway is emerging as an important tumor-evasion mechanism. In this issue of Blood, 3 independent groups report that PD-1 is highly expressed by tumor-specific cytotoxic T lymphocytes in hematologic and nonhematologic malignancies, and is associated with impaired T-cell function.


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