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Blood, 20 August 2009, Vol. 114, No. 8, pp. 1458-1459. This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Google Scholar Articles by Carroll, M. PubMed PubMed Citation Articles by Carroll, M. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  MYELOID NEOPLASIA Comment on Tamburini et al, page 1618 Taking aim at protein translation in AML Martin Carroll UNIVERSITY OF PENNSYLVANIA Abstract In this issue of Blood, Tamburini and colleagues have studied the regulation of protein translation control in primary AML cells and describe a mTORC1-independent mechanism of regulation of the translation initiation complex that can be targeted with 4EGI-1, a small molecule inhibitor of translation, leading to death of the cells.1 This and other recent studies add to a growing body of evidence that AML cells have a critical dependence on active protein translation, which may provide an Achilles' heel for the tumor cells that can be targeted therapeutically. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia Jerome Tamburini, Alexa S. Green, Valerie Bardet, Nicolas Chapuis, Sophie Park, Lise Willems, Madalina Uzunov, Norbert Ifrah, François Dreyfus, Catherine Lacombe, Patrick Mayeux, and Didier Bouscary Blood 2009 114: 1618-1627. [Abstract] [Full Text] [PDF]

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