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Blood, 20 August 2009, Vol. 114, No. 8, pp. 1645-1654. Prepublished online as a Blood First Edition Paper on June 11, 2009; DOI 10.1182/blood-2009-01-199414. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2009-01-199414v1 114/8/1645    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Google Scholar Articles by Sørensen, A. L. Articles by Hoffmeister, K. M. PubMed PubMed Citation Articles by Sørensen, A. L. Articles by Hoffmeister, K. M. Related Collections Platelets and Thrombopoiesis Thrombosis and Hemostasis Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  PLATELETS AND THROMBOPOIESIS Role of sialic acid for platelet life span: exposure of β-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor–expressing liver macrophages and hepatocytes Anne Louise Sørensen1,2, Viktoria Rumjantseva2,3, Sara Nayeb-Hashemi2, Henrik Clausen1, John H. Hartwig2, Hans H. Wandall1,2, and Karin M. Hoffmeister2 1 Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark; 2 Translational Medicine Division, Brigham and Women's Hospital, Boston, MA; and 3 Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden Although surface sialic acid is considered a key determinant for the survival of circulating blood cells and glycoproteins, its role in platelet circulation lifetime is not fully clarified. We show that thrombocytopenia in mice deficient in the St3gal4 sialyltransferase gene (St3Gal-IV–/– mice) is caused by the recognition of terminal galactose residues exposed on the platelet surface in the absence of sialylation. This results in accelerated platelet clearance by asialoglycoprotein receptor-expressing scavenger cells, a mechanism that was recently shown to induce thrombocytopenia during Streptococcus pneumoniae sepsis. We now identify platelet GPIb as a major counterreceptor on ST3Gal-IV–/– platelets for asialoglycoprotein receptors. Moreover, we report data that establish the importance of sialylation of the von Willebrand factor in its function. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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