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Blood, 27 August 2009, Vol. 114, No. 9, pp. 1722-1723.

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InsideBlood

PLATELETS & THROMBOPOIESIS

Comment on Gratacap et al, page 1884

The clot thickens (or not)

Steven E. McKenzie, and Michael P. Reilly

THOMAS JEFFERSON UNIVERSITY

Abstract

In this issue of Blood, Gratacap and colleagues analyze the effects of the multikinase inhibitor dasatinib on platelets, helping to explain the occurrence of bleeding related to its use for CML patients resistant to or intolerant of imatinib.1 In addition, by virtue of careful experimentation using multiple functional platelet assays, these authors are paving the way for the development of kinase inhibitors as antithrombotic agents.


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Related Article in Blood Online:

The new tyrosine-kinase inhibitor and anticancer drug dasatinib reversibly affects platelet activation in vitro and in vivo
Marie-Pierre Gratacap, Valérie Martin, Marie-Cécile Valéra, Sophie Allart, Cédric Garcia, Pierre Sié, Christian Recher, and Bernard Payrastre
Blood 2009 114: 1884-1892. [Abstract] [Full Text] [PDF]





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