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 Blood, 27 August 2009, Vol. 114, No. 9, pp. 1723-1724.

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InsideBlood

PLATELETS & THROMBOPOIESIS

Comment on Trifiro et al, page 1893

GPVI: the inside story

Alan Nurden

FRENCH REFERENCE CENTER FOR PLATELET DISORDERS

Abstract

The search is on for natural regulators of platelet reactivity. In this issue of Blood, Trifiro and colleagues confirm that the low frequency isoform of platelet GPVI (VIb) attenuates ligand-mediated signal transduction and dampens down platelet reactivity with collagen while not affecting GPVI receptor copy number.


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Related Article in Blood Online:

The low-frequency isoform of platelet glycoprotein VIb attenuates ligand-mediated signal transduction but not receptor expression or ligand binding
Elisabetta Trifiro, Shirley A. Williams, Yann Cheli, Kenichi Furihata, Fabio M. Pulcinelli, Diane J. Nugent, and Thomas J. Kunicki
Blood 2009 114: 1893-1899. [Abstract] [Full Text] [PDF]





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