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 Blood, 27 August 2009, Vol. 114, No. 9, pp. 1724-1725.

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InsideBlood

TRANSFUSION MEDICINE

Comment on Anani Sarab et al, page 1954

Processed platelet HPA1a peptides au naturel

John W. Semple

ST MICHAEL'S HOSPITAL

Abstract

An understanding of how helper T cells are activated to drive blood group immune responses will help to explain the immunogenicity of antigens such as HPA-1a. In this issue of Blood, Anani Sarab and colleagues identify the naturally processed HPA1a peptides recognized by T cells and set the stage for peptide-based therapies in NAIT.1


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Related Article in Blood Online:

Naturally processed peptides spanning the HPA-1a polymorphism are efficiently generated and displayed from platelet glycoprotein by HLA-DRB3*0101–positive antigen-presenting cells
Gholamreza Anani Sarab, Michael Moss, Robert N. Barker, and Stanislaw J. Urbaniak
Blood 2009 114: 1954-1957. [Abstract] [Full Text] [PDF]





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