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 Blood, 27 August 2009, Vol. 114, No. 9, pp. 1727-1728.

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InsideBlood

VASCULAR BIOLOGY

Comment on Lee et al, page 1987

The antitumorigenic trifecta

Yvonne M. Mowery, and Salvatore V. Pizzo

DUKE UNIVERSITY

Abstract

The laboratory of Judah Folkman identified the potent endogenous antiangiogenic protein angiostatin in 1994.1 In this issue of Blood, Lee and colleagues propose 2 new mechanisms of action for angiostatin that may represent promising targets for new cancer therapeutics.2


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Related Article in Blood Online:

Angiostatin regulates the expression of antiangiogenic and proapoptotic pathways via targeted inhibition of mitochondrial proteins
Tong-Young Lee, Stefan Muschal, Elke A. Pravda, Judah Folkman, Amir Abdollahi, and Kashi Javaherian
Blood 2009 114: 1987-1998. [Abstract] [Full Text] [PDF]





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