Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
 Blood, 27 August 2009, Vol. 114, No. 9, pp. 1947-1953.
Prepublished online as a Blood First Edition Paper on June 10, 2009; DOI 10.1182/blood-2009-04-218727.

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
blood-2009-04-218727v1
114/9/1947    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Google Scholar
Right arrow Articles by Nowak-Göttl, U.
Right arrow Articles by Stoll, M.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nowak-Göttl, U.
Right arrow Articles by Stoll, M.
Related Collections
Right arrow Thrombosis and Hemostasis
Right arrow Clinical Trials and Observations
Right arrowRelated Articles in Blood Online
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

THROMBOSIS AND HEMOSTASIS

Fibrinogen {alpha} and {gamma} genes and factor VLeiden in children with thromboembolism: results from 2 family-based association studies

Ulrike Nowak-Göttl1, Hartmut Weiler2, Irene Hernandez2, Sabine Thedieck1, Tanja Seehafer3, Thomas Schulte1, and Monika Stoll3

1 Pediatric Hematology/Oncology, University of Muenster, Muenster, Germany; 2 Blood Research Institute, Blood Center of Wisconsin, Milwaukee; and 3 Leibniz-Institute for Arteriosclerosis Research, Genetic Epidemiology of Vascular Disorders, Muenster, Germany

Previous case-control studies showed that genetic variation in the fibrinogen {gamma} gene (FGG) increased the risk for deep vein thrombosis (VT) in adults. We investigated the association between the fibrinogen {alpha} (FGA) and FGG haplotypes, the factor VLeiden-mutation, and pediatric VT and thromboembolic stroke (TS) in 2 independent study samples. Association analysis revealed that the FGA-H1 and FGG-H2 haplotypes were significantly overtransmitted to VT patients (FGA-H1, P = .05; FGG: H2, P = .032). In contrast, the FGG-H3 haplotype was undertransmitted (P = .022). In an independent study sample, FGA-H1 (P = .008) and FGG-H2 (P = .05) were significantly associated with TS. The association of FGA and FGG haplotypes with VT was more pronounced in FVLeiden-negative families (FGA-H1, P = .001; FGG-H2, P = .001), indicating a genetic interaction between both risk factors. The risk-conferring FGG-H2 and the protective FGG-H3 haplotypes correlated with low (FGG-H2) and high (FGG-H3) levels of the {gamma}' chain variant, respectively. These results provide independent and novel evidence that FGA-H1 and FGG-H2 variants are associated with an increased risk of VT and TS in children. The observed negative correlation of genetic VT risk with the plasma levels of the fibrinogen {gamma}' variant suggests that FGG-H2 and -H3 haplotypes modify thrombosis risk by controlling the level of this FGG splice isoform.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?

Related Articles in Blood Online:

Elevated fibrinogen {gamma}' ratio is associated with cardiovascular diseases and acute phase reaction but not with clinical outcome
Elim Y. L. Cheung, Hans L. Vos, Marieke J. H. A. Kruip, Heleen M. den Hertog, J. Wouter Jukema, and Moniek P. M. de Maat
Blood 2009 114: 4603-4604. [Full Text] [PDF]

Response: Elevated fibrinogen {gamma}' ratios and clinical outcomes
Ulrike Nowak-Göttl, Hartmut Weiler, and Monika Stoll
Blood 2009 114: 4604-4605. [Full Text] [PDF]



This article has been cited by other articles:


Home page
 BloodHome page
E. Y. L. Cheung, H. L. Vos, M. J. H. A. Kruip, H. M. den Hertog, J. W. Jukema, and M. P. M. de Maat
Elevated fibrinogen {gamma}' ratio is associated with cardiovascular diseases and acute phase reaction but not with clinical outcome
Blood, November 12, 2009; 114(20): 4603 - 4604.
[Full Text] [PDF]

Home page
 BloodHome page
U. Nowak-Gottl, H. Weiler, and M. Stoll
Response: Elevated fibrinogen {gamma}' ratios and clinical outcomes
Blood, November 12, 2009; 114(20): 4604 - 4605.
[Full Text] [PDF]

Home page
 BloodHome page
S. Uitte de Willige, K. F. Standeven, H. Philippou, and R. A. S. Ariens
The pleiotropic role of the fibrinogen {gamma}' chain in hemostasis
Blood, November 5, 2009; 114(19): 3994 - 4001.
[Abstract] [Full Text] [PDF]


click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2009 by American Society of Hematology         Online ISSN: 1528-0020