Blood, 1957, Vol. 12, No. 1, pp. 42-55.
© 1957 American Society of Hematology, Inc.
Autoimmune Hemolytic Anemia
I. Analysis of Hematologic Observations with Particular
Reference to Their Prognostic Value. A Survey of 57 Cases
WILLIAM H. CROSBY 1 and
HENRY RAPPAPORT 1
1 Armed Forces Institute of Pathology and the Department of Hematology,
Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington,
D. C.
1. The records of 57 patients with autoimmune hemolytic anemia have been
reviewed to learn if the hematologic data were of any prognostic importance.
It appeared that higher mortality was associated with severe anemia, reticulocytopenia, thrombocytopenia and leukopenia. The presence of spherocytosis and
erythroblastosis seemed to have no prognostic significance with regard to
mortality.
2. Thrombocytopenia in several patients was associated with thromboembolic disease.
3. There was a definite seasonal incidence of hemolytic crises in AHA, more
crises occurring during the winter months.
Submitted on April 17, 1956
Accepted on June 17, 1956