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Blood, 1960, Vol. 15, No. 2, pp. 277-284.
© 1960 American Society of Hematology, Inc.
Reticulum Cell Sarcoma Terminating in Acute Leukemia
J. LESTER ZEFFREN 1 and
JOHN E. ULTMANN 1
1 Department of Medicine, Columbia University College of Physicians and
Surgeons, and the Medical Service, Francis Delafield Hospital, New York, N. Y.
The records of 113 patients dying at the Francis Delafield Hospital with
documented reticulum cell sarcoma revealed six cases whose course terminated
in a syndrome resembling acute leukemia. Their course was characterized
by weakness, pallor, petechiae, hemorrhages and hepatosplenomegaly. The
blood showed anemia, leukocytosis (white blood cell count 20,000 to 80,000/
cu.mm.) and thrombocytopenia (platelet count [unknown] 100,000/cu.mm.). Differential count in the blood and the bone marrow revealed a high percentage of
immature cells (35 to 96 per cent). These were identified as reticulum cells
in three patients, as myeloblasts in two and as monocytoid granulocytes in one.
In all six patients, this explosive illness terminated in systemic infection or
hemorrhage within two months. Therapy with 6-mercaptopurine, adrenal
steroids, or both, gave no benefit.
Submitted on April 2, 1959
Accepted on June 18, 1959
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