Blood, 1960, Vol. 16, No. 1, pp. 975-983.
© 1960 American Society of Hematology, Inc.
Hemoglobin H Associated with an Uncommon Variant
of Thalassemia Trait
W. A. DITTMAN 1,
A. HAUT 1,
M. M. WINTROBE 1, and
G. E. CARTWRIGHT 1
1 Department of Medicine, University of Utah College of Medicine, Salt Lake
City, Utah.
A 26 year old American housewife of Sardinian extraction with chronic
hypochromic anemia was found to have a hemoglobin component identical
to hemoglobin H. The A2 hemoglobin fraction was decreased. Relatives were
found to exhibit the hematologic features of thalassemia trait. In this pedigree,
in contrast to the usual finding in the "thalassemia trait," the A2 values were
not increased. The same observation had been made in the only other comparable report.
Submitted on August 15, 1959
Accepted on November 20, 1959
