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Blood, 1961, Vol. 17, No. 1, pp. 20-44.
© 1961 American Society of Hematology, Inc.

Studies in Experimental Autoimmune Disorders. I. Clinical and Laboratory Features of Autoimmunization (Runt Disease) in the Mouse

HERMAN OLINER 1, ROBERT SCHWARTZ 1, WILLIAM DAMESHEK 1, and Lorraine Beldotti 1

1 Blood Research Laboratory, Pratt Diagnostic Clinic-New England Center Hospital, and the Department of Medicine, Tufts University School of Medicine.

The graft vs. host reaction (runt disease) was studied in LAF1, BDF1, and BAF1, mice. The disease was induced by the injection of parental splenic tissue into adult recipients.

The F1 hybrid recipients developed weight loss, hair changes, dermatitis, hypothermia and splenomegaly. The laboratory features included hemolytic anemia with a positive antiglobulin test, leukopenia, thrombocytopenia and abnormalities of their plasma electrophoretic patterns.

Certain similarities between runt disease and autoimmune diseases of man were suggested, and their significance was discussed.

Submitted on July 15, 1960
Accepted on October 5, 1960


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