Blood, 1961, Vol. 17, No. 3, pp. 345-350.
© 1961 American Society of Hematology, Inc.
Polycythemia Vera in Childhood. Studies of Iron Kinetics
with Fe59 and Blood Clotting Factors
P. M. AGGELER ,
M. POLLYCOVE ,
S. HOAG ,
W. G. DONALD , and
J. H. LAWRENCE
A case of polycythemia vera, first diagnosed in a nine year old girl, is
presented. The increase in red cell count, hematocrit and hemoglobin values
was accompanied by an increase in total blood volume and true red cell
volume. No other condition reported to be accompanied by polycythemia was
found. Specific, mild deficiencies in certain coagulation factors were found.
Iron kinetic study with Fe59 showed increased hemoglobin formation within
normal iron pathways which is characteristic of polycythemia vera.
Submitted on May 19, 1960
Accepted on December 9, 1960