|
|
 Previous Article | Table of Contents | Next Article 
Blood, 1961, Vol. 18, No. 2, pp. 149-165.
© 1961 American Society of Hematology, Inc.
The Mode of Inheritance of PTA Deficiency:
Evidence for the Existence of Major PTA
Deficiency and Minor PTA Deficiency
SAMUEL I. RAPAPORT 1,
ROBERT R. PROCTOR 1,
MARY JANE PATCH 1, and
MAURICE YETTRA 1
1 Department of Medicine, University of Southern California School of Medicine,
and the Southern California Permanente Medical Group and the Kaiser Foundation Hospital, Los Angeles, Calif.
Plasma thromboplastin antecedent (PTA) activity was measured with a
quantitative assay in the available members of the families of eight propositi
with severe PTA deficiency. PTA deficiency was found to exist in two forms:
major PTA deficiency, characterized by PTA levels of up to 20 per cent of our
standard reference plasma and by the potential for serious surgical bleeding,
and minor PTA deficiency, characterized by PTA levels between 30 and 65
per cent of our standard reference plasma and by the absence of significant
surgical bleeding. Minor PTA deficiency was found in parents and children
of subjects with major PTA deficiency.
It would appear that the gene for PTA deficiency is an incompletely recessive or "intermediate" gene which produces major PTA deficiency in the homozygote and minor PTA deficiency in the heterozygote.
Submitted on March 27, 1961
Accepted on May 16, 1961
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
D. V. Kravtsov, P. E. Monahan, and D. Gailani
A classification system for cross-reactive material-negative factor XI deficiency
Blood,
June 15, 2005;
105(12):
4671 - 4673.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. E. Schmidt, T. Ogawa, D. Gailani, and S. P. Bajaj
Structural Role of Gly193 in Serine Proteases: INVESTIGATIONS OF A G555E (GLY193 IN CHYMOTRYPSIN) MUTANT OF BLOOD COAGULATION FACTOR XI
J. Biol. Chem.,
July 9, 2004;
279(28):
29485 - 29492.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Seligsohn
A new mechanism for inherited factor XI deficiency
Blood,
July 1, 2004;
104(1):
7 - 8.
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C.M. Meijers, W. L.H. Tekelenburg, B. N. Bouma, R. M. Bertina, and F. R. Rosendaal
High Levels of Coagulation Factor XI as a Risk Factor for Venous Thrombosis
N. Engl. J. Med.,
March 9, 2000;
342(10):
696 - 701.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Martincic, V. Kravtsov, and D. Gailani
Factor XI Messenger RNA in Human Platelets
Blood,
November 15, 1999;
94(10):
3397 - 3404.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Martincic, S. A. Zimmerman, R. E. Ware, M.-F. Sun, J. A. Whitlock, and D. Gailani
Identification of Mutations and Polymorphisms in the Factor XI Genes of an African American Family by Dideoxyfingerprinting
Blood,
November 1, 1998;
92(9):
3309 - 3317.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Peretz, A. Mulai, S. Usher, A. Zivelin, A. Segal, Z. Weisman, M. Mittelman, H. Lupo, N. Lanir, B. Brenner, et al.
The Two Common Mutations Causing Factor XI Deficiency in Jews Stem From Distinct Founders: One of Ancient Middle Eastern Origin and Another of More Recent European Origin
Blood,
October 1, 1997;
90(7):
2654 - 2659.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Jokl and J. Federico
Myositis Ossificans Traumatica: Association With Hemophilia (Factor XI Deficiency) in a Football Player
JAMA,
May 16, 1977;
237(20):
2215 - 2216.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. B. Brodsky and G. E. Burgess III
Pulmonary Embolism With Factor XI Deficiency
JAMA,
December 15, 1975;
234(11):
1156 - 1157.
[Abstract]
[PDF]
|
|
|
|
|
|
|
N. R. SHULMAN, D. H. COWAN, E. P. LIBRE, S. P. WATKINS JR., and V. J. MARDER
The Physiologic Basis for Therapy of Classic Hemophilia (Factor VIII Deficiency) and Related Disorders: Combined Clinical Staff Conference at the National Institutes of Health
Ann Intern Med,
October 1, 1967;
67(4):
856 - 882.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. GOULIAN
A Guide to Disorders of Hemostasis
Ann Intern Med,
October 1, 1966;
65(4):
782 - 796.
[Abstract]
[PDF]
|
|
|
|
|
|
|
F. G. CONRAD, W. L. BRENEMAN, and D. B. GRISHAM
A Clinical Evaluation of Plasma Thromboplastin Antecedent (PTA) Deficiency
Ann Intern Med,
May 1, 1965;
62(5):
885 - 898.
[Abstract]
[PDF]
|
|
|
|
|
|
|
P. DIDISHEIM
Hageman Factor Deficiency (Hageman Trait) Case Report and Review of the Literature
Arch Intern Med,
August 1, 1962;
110(2):
170 - 177.
[Abstract]
[PDF]
|
|
|
|
|
|
|
F. A. Baglia and P. N. Walsh
Thrombin-mediated Feedback Activation of Factor XI on the Activated Platelet Surface Is Preferred over Contact Activation by Factor XIIa or Factor XIa
J. Biol. Chem.,
June 30, 2000;
275(27):
20514 - 20519.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
