Blood, 1961, Vol. 18, No. 3, pp. 364-369.
© 1961 American Society of Hematology, Inc.
Influence of Spleen on Thrombocytopenia Induced by
Humoral Factor(s) of Experimental Hypersplenism
RUY PÉREZ-TAMAYO 1,
SILVIA MEJIA 1, and
IRMGARD MONTFORT 1
1 United Patología de la Facultad de Medicina de la Universidad . Nacional
Antónoma de México, México, D. F.
The influence of the spleen on the thrombocytopenia induced in normal
rats by intragastric administration of humoral factor or factors [HF(s)] was
studied. Splenectomized rats showed the same thrombocytopenia associated
with administration of HF(s) as rats with intact spleen. Thrombocytopenia
established by two separate and disconnected periods of intragastric administration of HF(s) and followed by splenectomy was not modified. It is concluded that the spleen is not required by HF(s) to induce thrombocytopenia
in the normal rat, and also that the spleen does not participate in the maintenance of thrombocytopenia observed after discontinuation of HF(s).
Submitted on March 28, 1961
Accepted on May 16, 1961
