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Blood, 1962, Vol. 19, No. 3, pp. 304-312.
© 1962 American Society of Hematology, Inc.

Pyridoxine Responsive Anemia

JOHN N. BICKERS 1, CHARLES L. BROWN 1, CHARLES C. SPRAGUE 1, and Katherine Karst 1

1 Veterans Administration Hospital, and Tulane University School of Medicine, New Orleans, La.

A patient is reported with pyridoxine responsive anemia superimposed upon a chronic hypochromic anemia with excess iron storage. A specific response to pyridoxine was demonstrated on several occasions with restoration of the blood picture to its original state. Dietary estimates of vitamin B6 intake demonstrated an increased requirement for the vitamin, approximately 2.5 mg. per day being required for hematologic remission. Splenectomy was followed by high circulating siderocyte levels and severe thromboembolic problems. The possible mechanisms for the development of pyridoxine responsive anemia are discussed briefly.

Submitted on April 10, 1961
Accepted on December 7, 1961


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