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Blood, 15 October 2005, Vol. 106, No. 8, pp. 2890-2895.
Prepublished online as a Blood First Edition Paper on June 23, 2005; DOI 10.1182/blood-2005-03-1053.
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Submitted March 15, 2005
Accepted June 9, 2005
Persistent B19 infection in immunocompetent individuals: implications for transfusion safety
Jean Jacques LEFRERE, Annabelle SERVANT-DELMAS, Daniel CANDOTTI, Martine MARIOTTI, Isabelle THOMAS, Yvon BROSSARD, Francois LEFRERE, Robert GIROT, Jean-Pierre ALLAIN, and Syria LAPERCHE*
Departement des agents transmissibles par le Sang, Institut National de la Transfusion Sanguine, Paris, France; Laboratoire d'Hematologie, Centre Hospitalo-Universitaire, Amiens, France
Departement des agents transmissibles par le Sang, Institut National de la Transfusion Sanguine, Paris, France
National Blood Service, Cambridge, United Kingdom
Virology Unit, Scientific Institute of Public Health, Ministry of Public Health, Brussels, Belgium
Centre d'Hemobiologie Perinatale, Hopital Saint-Antoine, Paris, France
Service d'Hematologie Adultes, Hopital Necker, Paris, France
Laboratoire d'Hematologie, Hopital Tenon, Paris, France
Department of Haematology, Division of Transfusion Medicine, University of Cambridge, Cambridge, United Kingdom
* Corresponding author; email: slaperche{at}ints.fr.
Recent reports suggested that parvovirus B19 (B19) might persist in immunocompetent individuals such as blood donors, but only cross-sectional data were available. Serial samples from a cohort of multi-transfused patients with hemoglobinopathies and a cross-sectional population of pregnant women were tested for B19 markers. Six of 76 red cell recipients (8 %) had persistent viral DNA for one to three or more years, depending on the sensitivity of the genomic amplification assay. All patients also carried B19 specific IgG. In contrast, 0.8 % of 500 pregnant women carried both detectable B19 DNA and specific IgG. These results demonstrate that persistence of low levels of B19 DNA suggested by cross-sectional studies is frequent in multitransfused patients and that the virus may remain detectable several years after infection in non-immunodeficient individuals.
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