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Blood, 1966, Vol. 27, No. 4, pp. 435-448.
© 1966 American Society of Hematology, Inc.
Autoimmune Disease in NZB/Bl Mice
II. Autoimmunity and Malignant Lymphoma
ROBERT C. MELLORS 1,
Dolores A. Landy 1, and
David Bardell 1
1 Hospital for Special Surgery—Philip D. Wilson Research Foundation, affiliated
with the New York Hospital—Cornell University Medical College, and the Department of Pathology, Cornell University Medical College, New York, N. Y.
Malignant lymphoma was found in 4 of 20 NZB/Bl mice (of the 61st
generation) selected for laboratory examinations and autopsy at 9 to 11
months of age. The malignant lymphomas were of two histologic types, reticulum cell sarcoma and pleomorphic malignant lymphoma, the latter term being
used to designate malignant neoplasms arising in lymphatic tissue, composed
of mesenchymal cells of diverse appearance—mainly plasma cells of blast,
immature, mature and Russell-body types but also large primitive (stem)
cells, reticulum cells, and lymphocytes of large and small size—and frequently associated with gammopathies. One of the reticulum cell sarcomas
was transplantable to, and produced lethal disseminated growth in, other
NZB/Bl mice.
In each example of malignant lymphoma, warm hemagglutinins (to
papain-treated mouse red cells) were demonstrable in serum. Autoimmune
hemolytic disease and chronic membranous glomerulonephritis, both of common occurrence in NZB/Bl mice of comparable age, were also present. In
one instance of pleomorphic malignant lymphoma, hypergammaglobulinemia
of unusual quantity and quality drew attention to the possibility of lymphomatous disease.
Some evidence was brought forth indicating that in the majority of instances
the autoimmune diseases preceded the malignant lymphomas. While the
coexistence of autoimmunity and lymphoid neoplasia conceivably reflects
nothing more than chance occurrence, other interpretations were considered:
the proliferative advantage engendered in immunologically competent cells
in autoimmune disease may be a step in the direction of lymphoid neoplasia;
or, in some instances autoantibodies may be produced by, or in response to,
the neoplastic lymphoid cells.
Submitted on July 19, 1965
Accepted on August 20, 1965
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