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Blood, 1966, Vol. 27, No. 4, pp. 499-510.
© 1966 American Society of Hematology, Inc.


Origin of Auer Bodies

JAMES A. FREEMAN 1

1 Department of Pathology, Louisiana State University School of Medicine, New Orleans, Louisiana.

Evidence accrued by electron microscopic study of in vitro tissue-cultured leukemic cells supports Ackerman’s histochemical evidence that Auer bodies are formed from azurophilic granules, a circumstance first postulated by Nakashima in 1924. The enzymatic content and structure of these granules conforms to that of lysosomes, according to deDuve’s concept. Therefore the Auer body actually represents an unusual form, or abnormal development, of lysosomes.

Submitted on May 24, 1965
Accepted on July 19, 1965


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A. R. Davies and R. G. Schmitt
Auer Bodies In Mature Neutrophils
JAMA, March 4, 1968; 203(10): 895 - 895.
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