Blood, 1966, Vol. 27, No. 4, pp. 537-543.
© 1966 American Society of Hematology, Inc.
The Effect of Erythropoietin on Hematopoietic
Organs of the Polycythemic Mouse
K. NAKAO 1,
F. TAKAKU 1,
S. FUJIOKA 1, and
S. SASSA 1
1 Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Hongo, Tokyo, Japan.
Increased RNA-P32/DNA-P32 ratio, iron incorporation and heme synthesis
in spleens of polycythemic mice was demonstrated following an injection of
erythropoietin. These changes were correlated with the appearance of erythroblasts. These findings suggest an intimate relation between RNA synthesis
and stem cell differentiation.
Submitted on June 8, 1965
Accepted on July 25, 1965
