Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by DUVALL, C. P.
Right arrow Articles by PERRY, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by DUVALL, C. P.
Right arrow Articles by PERRY, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

Blood, 1967, Vol. 29, No. 4, pp. 652-666.
© 1967 American Society of Hematology, Inc.

Chronic Myelocytic Leukemia with Two Philadelphia Chromosomes and Prominent Peripheral Lymphadenopathy

CHARLES P. DUVALL 1, PAUL P. CARBONE 1, WILLIAM R. BELL 1, JACQUELINE WHANG 1, J. H. TJIO 1, and SEYMOUR PERRY 1

1 Medicine Branch, National Cancer Institute, and the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland.

1. Three adults with CML, 2 Ph1 chromosomes, and marked peripheral lymphadenopathy are described.

2. In each instance node enlargement was thought to be due to leukemic infiltration rather than a supervenient lymphomatous process.

3. Marked adenopathy is an unfavorable prognostic sign in CML, particularly if caused by myeloblastic infiltration. Such infiltration can precede myeloblastic involvement of the peripheral blood and bone marrow.

4. Karyotype analysis and touch preparations of extramedullary tumor tissue in CML will aid in accurate diagnosis and may help to answer more basic questions regarding the pathogenesis of this malignancy.

Submitted on July 5, 1966
Accepted on October 13, 1966


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 1967 by American Society of Hematology         Online ISSN: 1528-0020