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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by FAWWAZ, R. A. Articles by SARGENT, T. Search for Related Content PubMed PubMed Citation Articles by FAWWAZ, R. A. Articles by SARGENT, T. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1967, Vol. 30, No. 4, pp. 417-424. © 1967 American Society of Hematology, Inc. Hepatic Iron Deposition in Humans I. First-Pass Hepatic Deposition of Intestinally Absorbed Iron in Patients with Low Plasma Latent Iron-Binding Capacity R. A. FAWWAZ 1, H. S. WINCHELL 1, M. POLLYCOVE 1, and T. SARGENT 1 1 Donner Laboratory, University of California, Berkeley, Calif. In patients with spontaneous chronic low plasma latent iron-binding capacity, a large fraction of the intestinally absorbed iron is deposited in the liver without prior appearance in the systemic plasma. Such hepatic iron is not released to any large extent during the subsequent 2 weeks. Our results are consistent with the hypothesis that iron absorbed from the intestinal tract is not initially bound to transferrin. When the plasma latent iron-binding capacity is normal, iron binds to transferrin prior to reaching the liver; when the plasma latent iron-binding capacity is low, a portion of the iron reaches the liver either unbound or abnormally bound to transferrin, resulting in its immediate hepatic deposition. Submitted on November 21, 1966 Accepted on March 19, 1967 CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D Trinder, P S Oates, C Thomas, J Sadleir, and E H Morgan Localisation of divalent metal transporter 1 (DMT1) to the microvillus membrane of rat duodenal enterocytes in iron deficiency, but to hepatocytes in iron overload Gut, February 1, 2000; 46(2): 270 - 276. [Abstract] [Full Text] [PDF]

	Copyright © 1967 by American Society of Hematology         Online ISSN: 1528-0020