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Blood, 1968, Vol. 31, No. 6, pp. 719-726.
© 1968 American Society of Hematology, Inc.
The Ultrastructure of an Abnormal Cell
in Sézary’s Syndrome
MARVIN A. LUTZNER 1 and
HAROLD W. JORDAN 1
1 Dermatology Branch, National Cancer Institute, National Institutes of Health,
Bethesda, Maryland.
Sézary described a characteristic cell found in a syndrome which bears his
name. This syndrome is manifested by erythroderma, lymphadenopathy, and
abnormal circulating cells. The electron microscope was used to study skin,
lymph nodes, and blood from three Sézary patients and all demonstrated characteristic cells. The nucleus of this Sézary cell was strikingly irregular, indented, lobulated, and serpentine, often narrowed to a single row of nuclear particles. The cytoplasm exhibited no abnormalities. No abnormal cells similar to
those described have been found in any control tissues studied.
Submitted on September 7, 1967
Accepted on December 1, 1967
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