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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by LANGLEY, G. R. Articles by FELDERHOF, C. H. Search for Related Content PubMed PubMed Citation Articles by LANGLEY, G. R. Articles by FELDERHOF, C. H. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1968, Vol. 32, No. 4, pp. 569-585. © 1968 American Society of Hematology, Inc. Atypical Autohemolysis in Hereditary Spherocytosis as a Reflection of Two Cell Populations: Relationship of Cell Lipids to Conditioning by the Spleen G. R. LANGLEY 1 and C. H. FELDERHOF 1 1 Department of Medicine, Dalhousie University and the Victoria General Hospital, Halifax, Nova Scotia, Canada. Two patients with hereditary spherocytosis had increased autohemolysis not corrected by supplementary glucose, while an affected son of the second patient had a typical autohemolytic response with glucose. Almost one half of the circulating red cells in both patients had markedly increased osmotic fragility. When these were eliminated in vitro, by selective osmotic hemolysis, or in vivo by splenectomy, the autohemolysis response was corrected by glucose. The loss of this large population of extremely fragile cells after splenectomy suggested they were the product of conditioning by the spleen. In addition to having decreased osmotic resistance, an autohemolysis not corrected by glucose, and a short in vivo survival, these conditioned cells were smaller and had a considerable decrease in cell lipid. After splenectomy, with the loss of the most fragile cell population, cell size and lipid content increased. However in spite of no decrease in cell lipid after splenectomy, osmotic fragility remained abnormal. Increased osmotic fragility may be one of the earliest manifestations of a membrane abnormality in hereditary spherocytosis. Submitted on October 11, 1967 Accepted on March 27, 1968 CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. I. Weed Hereditary Spherocytosis: A Review Arch Intern Med, October 1, 1975; 135(10): 1316 - 1323. [Abstract] [PDF]

	Copyright © 1968 by American Society of Hematology         Online ISSN: 1528-0020