Blood, 1970, Vol. 36, No. 3, pp. 334-336.
© 1970 American Society of Hematology, Inc.
Leukocyte Antigen-Antibody Reaction and Lysis of
Paroxysmal Nocturnal Hemoglobinuria Erythrocytes
GIROLAMO SIRCHIA 1,
SOLDANO FERRONE 1, and
FRANCESCO MERCURIALI 1
1 Institute of Medical Pathology, University of Milan, Milan, Italy.
The interaction between leukocyte antigens and specific antibodies can cause
lysis of the red cells of paroxysmal nocturnal hemoglobinuria (PNH) in vitro.
It is suggested that the activation of
complement ensuing from the antigen-antibody interaction is responsible for
PNH cell lysis. The clinical implications
of this finding are briefly outlined.
Submitted on May 13, 1969
Revised on February 26, 1970
Accepted on March 9, 1970
