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Blood, 1971, Vol. 37, No. 1, pp. 47-51.
© 1971 American Society of Hematology, Inc.
Characterization of the Coagulant Activity of
Cultured Human Fibroblasts
DAVID GREEN 1,
CATHY RYAN 1,
NANCY MALANDRUCCOLO 1, and
HENRY L. NADLER 1
1 Hematology Section, Department of Medicine and The Children’s Memorial
Hospital, Northwestern University-McGaw Medical Center, Chicago, Ill.
Skin fibroblasts were cultured from
normal individuals, from patients with
hemophilia, and from known and
suspected carriers of hemophilia. All cell
lysates studied had similar coagulant
activity unaffected by incubation with
a specific antibody to factor VIII and,
therefore, presumably not factor VIII.
Further investigation indicated that the
coagulant had many properties indistinguishable from those associated with
"tissue factor," including heat lability,
sedimentation characteristics, and dependency on factor VII for expression of
coagulant activity. The presence of tissue
factor in skin fibroblasts is consistent
with the wide distribution of this coagulant, and the ability to maintain this material in tissue culture provides an
opportunity for further investigation of
the role of tissue factor in normal and
pathologic states.
Submitted on May 22, 1970
Revised on August 20, 1970
Accepted on August 21, 1970
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