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Blood, 1971, Vol. 38, No. 5, pp. 576-582.
© 1971 American Society of Hematology, Inc.

Pure Red Cell Aplasia and Thymoma: Loss of Serum Inhibitor of Erythropoiesis Following Thymectomy

HAMID AL-MONDHIRY 1, ESMAIL D. ZANJANI 1, MORTON SPIVACK 1, RALPH ZALUSKY 1, and ALBERT S. GORDON 1

1 Division of Hematology, Department of Medicine, Montefiore Hospital and Medical Center, Bronx, N.Y.; The Laboratory of Experimental Hematology, Department of Biology, Graduate School of Arts and Science, New York University, New York, N. Y.; Section of Hematology, Morrisania-Montefiore Affiliation, Bronx, N. Y.; and the Department of Medicine (Hematology), Mount Sinai School of Medicine of the City University of New York, New York, N. Y.

A 32-yr-old black female with pure red cell aplasia and thymoma showed complete hematologic remission after thymectomy. Bioassay of preoperative serum and urine in exhypoxic polycythemic mice revealed the presence of significant levels of erythropoiesis-stimulating factor (ESF or erythropoietin). Antierythropoietin completely neutralized the erythropoietic effect of these samples. Utilizing both normal and exhypoxic polycythemic mice, the preoperative serum and urine were also found to contain a potent inhibitor of erythropoiesis. However, no such activity was demonstrated in saline extracts of the tumor tissue. The inhibitor was present in the serum IgG fraction. Serum to which excess ESF had been added, after prior neutralization of endogenous ESF with anti-ESF, failed to stimulate erythropoiesis in the polycythemic mouse.

Submitted on January 10, 1971
Revised on June 9, 1971
Accepted on June 15, 1971


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