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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by de Furia, F. G. Articles by Miller, D. R. Search for Related Content PubMed PubMed Citation Articles by de Furia, F. G. Articles by Miller, D. R. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1972, Vol. 39, No. 3, pp. 398-406. © 1972 American Society of Hematology, Inc. Oxygen Affinity in Hemoglobin Köln Disease Frank G. de Furia 1 and Denis R. Miller 1 1 Department of Pediatrics and Medicine, New York Hospital, Cornell University Medical College, New York. Oxygen affinity studies in a splenectomized patient with sporadically occurring Hb Köln disease revealed high whole blood oxygen affinity (P50 O2 17.6 mm Hg) with increased 2, 3-diphosphoglycerate (DPG), low ATP, and normal RBC pH. Isolated electrophoretically slow migrating Hb Köln had a high oxygen affinity, decreased Hill’s number, and normal DPG reactivity. Functional evidence for hybrid tetramers with normal mobility is presented. Partial deoxygenation may play a role in the denaturation of the Hb Köln molecule and thus account for a higher oxygen affinity (low P50 O2), measured by the mixing technique, than the actual values for P50 that exist in vivo. Increased oxygen affinity and decreased P50 O2 would result in increased erythropoiesis and account for a well-compensated hemolytic process in this patient with a normal red cell mass and normal values of hemoglobin. Submitted on August 9, 1971 Revised on September 15, 1971 Accepted on September 20, 1971 CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. D. Woodson, J. D. Heywood, and C. Lenfant Oxygen Transport in Hemoglobin Koln: Effect of Increased Oxygen Affinity in Absence of Compensatory Erythrocytosis Arch Intern Med, October 1, 1974; 134(4): 711 - 715. [Abstract] [PDF]

	Copyright © 1972 by American Society of Hematology         Online ISSN: 1528-0020