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1 Naval Blood Research Laboratory, Chelsea, Mass.
The main feature of this new approach
to platelet freezing is a controlled rate
of addition and postthaw removal of
5% dimethylsulfoxide (DMSO). When
DMSO was removed from fresh nonfrozen platelet concentrates before
transfusion, no adverse effect on posttransfusion survival was observed. The
51Cr recovery of autologous fresh
platelet concentrates in vivo was 65%
± 5%, while that of autologous platelets previously frozen with DMSO and
washed prior to transfusion was 47%
± 3%. The lifespan values were similar
for fresh platelets and previously
frozen washed platelet concentrates.
When approximately 95% of the DMSO
was removed from previously frozen
washed platelets before transfusion,
the 51Cr recovery was about 70% of
the value for fresh platelet concentrates, and the lifespan value was similar to that of fresh platelet concentrates. No adverse side effects were
observed. The hemostatic effectiveness of these platelets has yet to be
studied.
This article has been cited by other articles:
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| Copyright © 1972 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
