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Blood, 1972, Vol. 40, No. 4, pp. 550-559.
© 1972 American Society of Hematology, Inc.
The Zeta Sedimentation Ratio
Brian S. Bull 1 and
J. Douglas Brailsford 1
1 Department of Pathology, School of Medicine, and the Department of Medical
Technology, School of Allied Health Professions, Loma Linda University, Loma Linda, Calif.
The zeta sedimentation ratio (ZSR)
is a measurement similar to the determination of the erythrocyte sedimentation rate (ESR) but possesses sevaral
advantages. It is unaffected by anemia
and responds in a linear manner to
increase in fibrinogen and/or gamma
globulin. The normal range is identical
for males and females. A blood sample,
contained within a vertically oriented
capillary tube, is subjected to four
cycles of dispersion and compaction.
At the conclusion of this process, the
hematocrit of the blood in the red
cell-containing portion of the capillary
tube is measured. This hematocrit, a
measure of the closeness with which
red cells will approach each other
under a standardized stress, is the
ZSR.
Submitted on February 18, 1972
Revised on April 18, 1972
Accepted on May 15, 1972
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