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Blood, 1972, Vol. 40, No. 5, pp. 719-724.
© 1972 American Society of Hematology, Inc.
Incidence of Monoclonal Proteins in a Minnesota
Community With a Cluster of Multiple Myeloma
Robert A. Kyle 1,
Sidney Finkelstein 1,
Lila R. Elveback 1, and
Leonard T. Kurland 1
1 Mayo Clinic and Mayo Foundation, Rochester, Minn.
Multiple myeloma was diagnosed in
six residents of Thief River Falls, Minn.
in 1968 (a rate of 84/100,000). A survey of the normal population for monoclonal serum protein peaks was undertaken in 1969. Serum from 1200 residents of the city, who were 50 yr of
age or older, was collected. Fifteen
(1.25%) had monoclonal serum protein
peaks: IgG in 11, IgA in one, and IgM
in three, with kappa in 11 and lambda
in four. No clinical, laboratory, or
roentgenographic evidence of myeloma or macroglobulinemia was
found in any of the patients. The
incidence of monoclonal serum protein peaks is similar to that reported
from Sweden. It was concluded that
there was no significant increase in
monoclonal proteins in the population
of Thief River Falls. The 1968 socalled epidemic of multiple myeloma
in Thief River Falls remains unexplained.
Submitted on May 4, 1972
Revised on May 24, 1972
Accepted on May 29, 1972
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