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Blood, 1973, Vol. 42, No. 4, pp. 571-577.
© 1973 American Society of Hematology, Inc.

Pancytopenia and Leukemia in Hodgkin’s Disease: Report of Three Cases

P. L. Weiden 1, K. G. Lerner 1, A. Gerdes 1, J. D. Heywood 1, A. Fefer 1, and E. D. Thomas 1

1 Departments of Medicine, Pathology, Radiation Oncology and Laboratory Medicine, University of Washington School of Medicine, Seattle, Wash. 98195, and the United States Public Health Service Hospital, Seattle, Wash. 98114.

Three patients with Hodgkin’s disease who developed severe pancytopenia terminating in acute leukemia (two patients) or preleukemia (one patient) are presented. Prior treatment consisted of radiation therapy alone in two patients, and radiation plus chemotherapy in the third. The only patient in whom chromosomal analysis was performed showed an abnormal chromosome. Therapeutic radiation exposure is thought to contribute to the development of leukemia in such patients. Leukemia is an uncommon complication of Hodgkin’s disease, but is being reported with increasing frequency. The rapid evolution of more aggressive modes of therapy makes it imperative that we seek more information regarding the incidence of this complication in order to achieve maximum therapeutic benefit for patients with Hodgkin’s disease.

Submitted on February 5, 1973
Revised on March 28, 1973
Accepted on April 2, 1973


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M. KITAHARA, T. M. COSGRIFF, and H. J. EYRE
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Ann Intern Med, May 1, 1980; 92(5): 625 - 627.
[Abstract] [PDF]


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